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Injecting healthy mitochondria into the brain was able to reverse all the problems.[ref] Targeted reversal of oxidative stress alleviates depression symptoms: Animal studies also show that targeting mitochondrial oxidative stress via increasing SIRT3 levels reverses depression via reducing oxidative stress.[ref] Direct link to brain plasticity: Researchers used primates to show that malformed and misshapen mitochondria result in fewer synaptic contacts in the brain.[ref] Brain energy, mood, and neurocognitive function: The brain uses more energy than any other organ in the body