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Other studies of adults with fibrotic airway disorders (251) and chronic obstructive pulmonary disease (252) have demonstrated reduced glutaredoxin 1 expression in bronchial epithelium and airway macrophages that associated with increased airflow limitation

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ROS also induces melanocytes to adopt a senescence-associated secretory phenotype (SASP), where they express pro-inflammatory cytokines that inhibit melanocyte proliferation and recruit immune cells to clear the “senescent melanocytes.” Furthermore, endoplasmic reticulum dysfunction in vitiligo patients exacerbates oxidative stress abnormalities and stimulates the secretion of IL-6 and IL-8, triggering immune responses

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