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[4] [5] Effects of supplementation [edit] Glutamate transmission modulation [edit] Due to ALCAR being an endogenous acetyl-group donator, it also acts as a histone acetylator of a specific subunit of Nuclear Factor kappa-light-chain-enhancer of activated B Cells (NF-κB), specifically the p65 subunit, which causes an upregulation of Metabotropic Glutamate Receptor 2 (mGluR2)

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BMC Res Notes 10 , 77