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That's because ever since the Industrial Revolution, heavy metals have been used in everything from paint (think lead) to the cars we drive, the materials our houses are built out of, even the smartphones we're glued to

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This method is based on the premise that thiols and persulfides act as nucleophiles, and so in the first step, a thiol blocking reagent is introduced to tag both P-SH and P-SSH (forming intermediate T) (Fig