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Degree of pathologic response after preoperative chemoradiotherapy correlates with failure patterns and outcome of patients with carcinoma of the esophagus

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This forms a complete regulatory cascade:NNMT inhibition → NAD+ elevation → metabolic optimization This unique mechanism makes 5-amino-1-methylquinolinium injection a critical tool linking NNMT activity, nicotinamide metabolism, and systemic metabolic homeostasis, providing direct experimental support for exploring NNMT's role in energy metabolism