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In the circulation, approximately 99% of the IGF-I pool is bound with high affinity to the IGFBPs that circulate in molar excess of IGF-I, thus explaining that less than 1% circulates as free, unbound IGF-I (7)

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Effects of N-Acetylcysteine on the Cardiac Remodeling Biomarkers and Major Adverse Events Following Acute Myocardial Infarction: a Randomized Clinical Trial