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Interestingly, ursodeoxycholic acid (UDCA), the only medication approved by the FDA for the treatment of primary biliary cirrhosis [152], a chronic cholestatic disorder, and SAMe were able to raise nuclear Nrf2 level, block the increase in MafG and c-Maf expression, protect against the fall in expression of GSH synthetic enzymes and GSH levels in these models [90,136]

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sanguinis ) as this genus influences gut-derived serotonin (Tanelian et al., 2023), which is partly controlled by the microbiota (Fung et al., 2017) and is known contributor to PTSD symptoms (Tanelian et al., 2023)