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It holds significant importance as a vital endocrine organ that synthesizes and secretes thyroid hormones 2 and possesses a crucial role in regulating energy and metabolism 3

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93 used low concentrations of the ALK4/5/7 kinase inhibitor SB-505124 to maintain TGF-β-induced Smad2/3 signaling, which is crucial for cartilage homeostasis, while blocking the harmful Smad1/5/9 pathway that contributes to chondrocyte hypertrophy and OA progression, as evidenced by decreased expression of Runx2 and Col10a1