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This enzyme is crucial for the final step in testosterone biosynthesis, making its inhibition particularly devastating for androgen production ( 3.2.1.2 Aromatase (CYP19) dysregulation EED exposure paradoxically upregulates CYP19 mRNA expression by 2.3-fold while simultaneously increasing catalytic activity (Vmax) by 56%

Adrenals

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Science 2018;359:6372