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The rates and mechanism by which metals are exchanged between donor and acceptor remains understudied, but must be dictated in part by their position along a continuum of divalent metal stability constants with simple organic ligands, known as the Irving-Williams series (Figure 7)

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Sagittal 4 μm paraffin sections of the brain were mounted on slides, which were rehydrated and incubated in a citrate buffer at 95°C for 30 minutes for antigen retrieval