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Common side effects of Simponi include: Upper respiratory tract infection Reaction at the site of the injection Viral infections (such as flu and oral cold sores) Other, more serious side effects, can include: Serious infections (including TB) Hepatitis B infection in people who carry the virus in their blood Heart failure Nervous system problems Immune system problems (rarely some people have developed symptoms similar to Lupus) Liver problems Blood problems Allergic reactions Psoriasis Children and adults taking TNF blockers - such as Simponi - there may be an increased risk in getting lymphoma or other cancers