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Diluting that into an adult’s ~3 litres of plasma changes the arithmetic considerably, but the point stands: the vial format was designed around commercial convenience, not around any dose that the mechanistic literature identified as biologically relevant

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New laboratory methods for the measurement of CRP have been developed and these sensitive CRP measurements can detect lower levels of CRP which are significantly related to certain inflammatory diseases and cardiovascular diseases[16, 17, 18, 19]