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Growth Hormone: Your Body's Most Potent Fat-Burning Hormone Growth hormone directly triggers lipolysis (fat breakdown) through several pathways: Activates hormone-sensitive lipase – the enzyme that breaks down stored triglycerides into free fatty acids Increases fatty acid oxidation – your mitochondria burn more fat for energy Reduces lipogenesis – less dietary fat gets stored in adipose tissue Improves insulin sensitivity – better glucose metabolism means less fat storage Why Declining GH Makes Fat Loss So Difficult After age 30, natural GH production declines approximately 14% per decade