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If you are sleep-deprived, your body produces excess cortisol, which suppresses the immune system and hinders the action of repair cells
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There is also an increased sensitization of the excitatory neurotransmitter system, such as NMDA glutamate receptors, the reduction in the number of GABA receptors (downregulation), the shift of benzodiazepine receptors to an inverse agonist state, and compensatory changes in other components of the macromolecular GABA/benzodiazepine/chloride ionophore complex (for review see, i.e., [219,220,221,222,223,224,225])