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Bioavailability remains a major translational challenge for oral curcumin, which undergoes rapid metabolism and shows limited systemic exposure unless delivered through optimized formulations (e.g., liposomes, nano-phytosomes)

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[DOI] [PubMed] [Google Scholar] 113.Tam O.H., Rozhkov N.V., Shaw R., Kim D., Hubbard I., Fennessey S., Propp N., Fagegaltier D., Harris B.T., Ostrow L.W., et al