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The Institutional Review Board of Shinshu University School of Medicine approved the study plans, and granted a waiver of informed consent, since diagnostic use of the samples was completed before this study and there was no risk to the patients

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Depletion of NNT in human melanocytes leads to increased ROS, increased TYR stability, and increased melanogenesis independent of UVR and MITF (Allouche et al., 2021)