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PKC enzyme: Apart from the involvement of PKC on the induction of oxidative stress in neurons, both human and animal studies have linked this enzyme to several pain types through excessive Ca 2+ entry and cation channel activation (Carozzi et al., 2017)

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Actemra acts as an IL-6 receptor antagonist, reducing inflammation by blocking pro-inflammatory signals, while Orencia modulates T-cell activation to control immune responses