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In addition to functional similarities, there is sequence homology between AngIV, its analogs, and a small, six-amino-acid domain of HGF termed the “hinge” region, which participates in the process of HGF dimerization (Kawas et al., 2012)

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AOD 9604 has the stronger direct mechanistic argument for isolated fat loss: it mimics the lipolytic fragment of hGH without triggering anabolic or insulinogenic pathways, and it has Phase II human RCT data showing weight reduction, even if modest