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Lack of TDP-43 leads to perturbed transcriptome in axon and dendrites and dysregulated transcripts code for genes that are key component of mRNA translation, cytoskeleton, and mitochondria mediated energy production and metabolism 35

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For instance, NAD + levels and mitochondrial function have been shown to decline in sarcopenia muscle in one cohort 249 , while another study did not observe a difference in NAD + levels in sarcopenic muscle, and even NR supplementation had no effect on NAD + levels 262