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It may be especially noted that, in the active site of enzymes, the contribution of solvation from water is usually minimal and thus the information gained by exploiting some sophisticated techniques of modern mass spectrometry may better contribute to understanding biochemical mechanisms

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Sitagliptin/metformin improves the fertilization rate and embryo quality in polycystic ovary syndrome patients through increasing the expression of gdf9 and bmp15: a new alternative to metformin (a randomized trial)