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Both Botox and SNAP-8/Argireline: Target the SNARE complex at neuromuscular junctions Specifically involve the SNAP-25 protein Reduce acetylcholine release at nerve-muscle junctions Result in reduced muscle contraction in treated facial areas Produce progressive reduction in the depth and frequency of expression lines The fundamental difference is delivery and magnitude: Botox is injected into the muscle at high concentration, producing complete blockade