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It will often not happen on the first GSH (it can of course) – but if there are methyl cycle slow downs and then yOu supply the B Vit cofactors and a methyl donor “suddenly” the methyl cycle donates more and more to the HCYS-Cystathionine pathway (which primes sulfite formation and SUOX) and THEN you give GSH which also donates to the same pathway… A sulfite reaction can look like anaphylaxis and can have hive reactions and all you mention