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Though testing is always needed before extrapolating animal dosing to human dosing, this 5mg/kg dose is approximately equivalent to 0.4mg/kg in humans based on human equivalent dose calculations provided by the FDA

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The concentration of all metabolites was calculated relative to the unsuppressed water spectrum and expressed as %water signal (IMCL and EMCL) or in absolute concentration values (all other metabolites) calculated using the following formula: Where [M] is the metabolite concentration and [W] is the water concentration (55 M)