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In summary, VAX-D shows promising results in reducing pain and nerve compression in some patients, but it also carries possible risks

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Rapid activation of a bypassing loop[21-25] occurs in rats with an infrarenal ligation of the inferior vena cava, relieving a Virchow's triad situation[21], much like in rats with ischemic/reperfusion colitis[22], duodenal venous congestion lesions[23], perforated cecum[24], bile duct ligation induced liver cirrhosis and portal hypertension[25]