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Indeed, in a 2025 study, skin care products made with Lactobacillus ferment lysate were found to reduce facial erythema within two weeks,58 and another 2025 study observed that Lactococcus ferment lysate could reduce acne severity, sebum levels, and inflammatory factors on the skin.59 Reishi and shiitake extracts Reishi and shiitake mushrooms have also shown some utility in the skin care space

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This study paved the way for subsequent anti-aging research involving epithalon [5]