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This event was, however, not necessarily preceded by an oxidative burst and later on we demonstrated that GSH release was the result of an active process that the cells carried out through specific carriers in order to efficiently execute the apoptotic program (Ghibelli et al., 1998)

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Simultaneously, the iron released by Fe 3 O 4 nanoparticles synergistically interacted with SSZ, producing a synergistic ferroptosis effect