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or i.g., without adverse effects was shown in mice, and a lethal dose (LD1) was not achieved, which also shows metabolites without harmful effect [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40]