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The first step of the procedure is the abdominal reduction of HH contents by gentle traction of the hernia sac, proceeding gradually with extensive mediastinal mobilization of the esophagus with blunt dissection in order to obtain at least 2-2.5 cm of intra-abdominal esophageal length [Figure 1A and B] [21]

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Most research on BPC-157, TB-500, and their combination has been conducted in preclinical animal models