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Two trials in acutely hospitalized patients have shown that short-term (around 7 days) vitamin C supplementation increased concentrations of ascorbic acid in plasma and leukocytes and led to 34-35% improvements in mood state, as measured by POMS (142, 143)

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10.1016/s0928-4257(97)89480-6 [DOI] [PubMed] [Google Scholar] Selye H., Szabo S