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For example, the intervention of KEAP1 inhibitors, such as natural coumarins, promotes Nrf2 activation, which reduces oxidative stress and inflammation in IBD by inhibiting NF-κB and enhancing antioxidant responses, as documented (261)

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Although the metal-binding and crystallization-promoting activities of these sequence tags are critical to their use, it must be clear that minimizing any inherent flexibility of the protein termini will increase the chance of success, and accurate domain boundaries should be determined from homology modelling or protease digest experiments