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Topical irritation management includes discontinuation for 24-48 hours, followed by concentration reduction of 50% upon resumption [3]

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Guided by this observation, we administered daily intraperitoneal injections of saline or uridine (1, 5, 10, or 20 mg/mL in saline) to young (6–8 weeks) and aged (48–56 weeks) female mice for ten consecutive days (Fig