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PMID 38489193) tested Dihexa (also documented as PNB-0408) in a 3-nitropropionic-acid rat model of Huntington's-disease-like motor and metabolic symptoms and reported that the compound did not attenuate the 3-NP-induced deficits — a null result the authors present as an argument for further work in alternate models rather than as evidence of efficacy in this one

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Low energy and oxidative damage cause aneuploidy and embryo arrest