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Interestingly, several studies have indicated that ApoE-null mice display a diminished microglial response to plaques, implying a potential regulatory role of ApoE in the microglial response to amyloid plaques (Ulrich et al., 2018

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REDEFINE 1 demonstrated 20.4% weight loss with 60% of patients achieving 20%+ reduction, substantially exceeding semaglutide alone