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The specific role of ferroptosis in ALD is still under study, and as cell ferroptosis itself is a complex process, its potential molecular mechanisms are currently not very clear

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Subject Areas: biological sciences, cell biology, functional aspects of cell biology Graphical Abstract Highlights • Inhibiting nutrient catabolism alleviates ER stress in metabolically active cells • NADPH production and glutathione redox link TCA activity to ER homeostasis • ER client protein oxidation, maturation, and ERAD respond to metabolic activity • Cells lacking the Mitochondrial Pyruvate Carrier are resistant to ER stress biological sciences