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The mechanism behind oral efficacy is attributed to systemic absorption and downstream peptide signaling rather than localized delivery, though the exact bioavailability percentage in humans remains unquantified

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The FDA’s own language makes it clear: “Compounded drugs containing BPC-157 may pose risk for immunogenicity … and may have complexities with regard to peptide-related impurities and API characterization.” In plain terms, the FDA is worried about shady, unregulated “research-use-only” peptides sold online — not about what happens when BPC-157 is responsibly compounded, tested for purity, and dispensed under medical supervision