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AOD-9604 does not suppress the HPTA, does not aromatize, does not elevate IGF-1, and does not impair glucose tolerance — which is the entire design rationale of the 177-191 fragment: "Chronic oral administration of AOD9604 induced a reduction in body weight and body fat, with no change in insulin, glucose, or IGF-I levels." — Heffernan et al., Am J Physiol Endocrinol Metab (2000) Hard contraindications# Pregnancy and lactation — untested

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Guidelines of care for the management of psoriasis and psoriatic arthritis: section 1